Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Moderately Good
Based on 34 Reviews
7.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Red Yeast Rice (Monascus purpureus)
1,200 mg
Coenzyme Q10 (Ubiquinone)
100 mg

Top Medical Research Studies

We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
Read More
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.

The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.

Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
Read More
9
Coenzyme Q10 enhances heart failure outcomes
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.

The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.

Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
Read More

Most Useful Reviews

7.5
No side effects
141 people found this helpful
This supplement works well for cardiovascular disease. I take it on my doctor's recommendation to lower my cholesterol, as I don’t tolerate statins. There are no side effects, and my test results have improved slightly, so I will continue taking it.
Read More
7.5
Alternative to statins
44 people found this helpful
Red yeast rice is beneficial for those who cannot tolerate statins. It may lower cholesterol levels, but consulting a healthcare professional is essential. This supplement can complement Co-Q10, vital for cardiovascular disease management. I noticed improvements in my cholesterol after using this for two months.
Read More
9
Improved energy
43 people found this helpful
Red yeast rice effectively lowers bad cholesterol without side effects. I felt great on this supplement, which also boosts energy and supports cardiovascular disease health through the coenzyme in its composition. I recommend the Jarrow brand for its reliability.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
  • All Researches
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.

The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.

Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
Read More
9
Coenzyme Q10 enhances heart failure outcomes
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.

The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.

Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
Read More
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
Read More
9
Coenzyme Q10 improves heart health
We conducted a thorough investigation into the effects of coenzyme Q10 on cardiovascular health in patients suffering from Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD). In this well-structured study, we utilized a randomized double-blind approach, dividing sixty participants to receive either 240 mg of coenzyme Q10 or a placebo daily for six months.

Our findings revealed that those taking coenzyme Q10 experienced significant improvements in several cardiovascular and liver health markers. Specifically, we noted reduced liver fat and enhanced endothelial function, indicating healthier blood vessels. Measurements showed positive changes in their vascular and myocardial functions, which are critical indicators of heart health.

Conversely, patients in the placebo group did not show any improvement throughout the study period. The results were compelling, underscoring not only the potential of coenzyme Q10 in mitigating liver steatosis but also its role in significantly boosting cardiovascular health.

Overall, by the end of our six-month research period, we observed a marked connection between improvements in liver function and cardiovascular markers, suggesting that coenzyme Q10 might be a beneficial treatment for those grappling with MASLD and associated cardiovascular risks.
Read More
9
CoQ10 aids in mitigating tissue damage
We aimed to understand how Coenzyme Q10 (CoQ10) might help counteract the damage caused by doxorubicin, a common chemotherapy drug known for its harmful side effects on the heart and lungs. To investigate this, we conducted a study involving 27 rats divided into three groups: one group received CoQ10, another received doxorubicin, and the last group received both.

At the end of the study, we examined the hearts and lungs of the rats. Our findings revealed that doxorubicin led to significant harm to the cellular structures in both organs, confirming the drug's cardiotoxic and pulmonary damaging effects. However, when CoQ10 was administered, it showed a promising ability to alleviate these adverse effects, almost restoring the normal appearance of the tissues.

In summary, our study suggests that CoQ10 could act as a protective agent, helping to maintain healthy lung and heart tissues in the context of doxorubicin treatment. This could potentially offer a valuable strategy for enhancing the safety and efficacy of chemotherapy regimens.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 34 Reviews
7.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
No side effects
141 people found this helpful
This supplement works well for cardiovascular disease. I take it on my doctor's recommendation to lower my cholesterol, as I don’t tolerate statins. There are no side effects, and my test results have improved slightly, so I will continue taking it.
Read More
7.5
Alternative to statins
44 people found this helpful
Red yeast rice is beneficial for those who cannot tolerate statins. It may lower cholesterol levels, but consulting a healthcare professional is essential. This supplement can complement Co-Q10, vital for cardiovascular disease management. I noticed improvements in my cholesterol after using this for two months.
Read More
9
Improved energy
43 people found this helpful
Red yeast rice effectively lowers bad cholesterol without side effects. I felt great on this supplement, which also boosts energy and supports cardiovascular disease health through the coenzyme in its composition. I recommend the Jarrow brand for its reliability.
Read More
9
Cholesterol control
29 people found this helpful
Excellent product! This comprehensive supplement supports normal cholesterol levels and cardiovascular disease health. Additionally, red yeast rice has antiviral properties, which makes it even more beneficial. I highly recommend it.
Read More
9
Quality product
4 people found this helpful
Red yeast rice boosts metabolism, promotes blood circulation, and supports liver and kidney functions. It effectively regulates cholesterol synthesis, while CoQ10 enhances mitochondrial energy production, protects cells, and positively affects cardiovascular disease. This is a high-quality product I recommend.
Read More

Frequently Asked Questions

8
Improved cholesterol tests
1 people found this helpful
I take it as prescribed to reduce bad cholesterol and support my cardiovascular health. Improvements in cholesterol tests were evident within a month. The capsules are easy to swallow, and the inclusion of Q10 enhances efficacy. A remarkable product.
7.5
Alternative to statins
44 people found this helpful
Red yeast rice is beneficial for those who cannot tolerate statins. It may lower cholesterol levels, but consulting a healthcare professional is essential. This supplement can complement Co-Q10, vital for cardiovascular disease management. I noticed improvements in my cholesterol after using this for two months.
9
Significant reduction
1 people found this helpful
I ordered Red Yeast Rice with Q10 to lower bad cholesterol and reduce heart disease risk. After two months, my cholesterol decreased by 25 per cent. I highly recommend it for those struggling with cholesterol issues.
9
Cholesterol reduction
2 people found this helpful
I took two bottles, and my LDL dropped from 4.6 (HIGH) to 3.5 (BORDERLINE). I was surprised as my diet hasn’t changed much, and I don’t eat fatty foods. I also have high cholesterol, potentially due to genetics. I’ve tried various remedies, but they were ineffective.
7.5
No side effects
141 people found this helpful
This supplement works well for cardiovascular disease. I take it on my doctor's recommendation to lower my cholesterol, as I don’t tolerate statins. There are no side effects, and my test results have improved slightly, so I will continue taking it.
7.5
Heart health improvement
2 people found this helpful
Jarrow Formulas Vegan Red Yeast Rice + Co-Q10 is excellent for supporting cardiovascular health. The veggie capsules are easy to swallow, and after consistent use, I noticed an improvement in my heart health and energy levels. Highly recommended for those seeking natural heart support!
9
Cardiovascular protection
1 people found this helpful
A six-month clinical trial showed that red yeast rice combined with Co-Q10 effectively reduces low-density cholesterol and improves vascular function. The results demonstrate positive outcomes for cardiovascular disease protection.
7.5
Effective results
5 people found this helpful
This medication genuinely works. I took it for over a month with Omega 3, starting with two capsules then one. More walking increased my activity, and my bad cholesterol decreased, enhancing my cardiovascular disease health. I recommend it over statins.
7.5
Energy boost
CoQ10 boosts energy, and red yeast rice enhances cardiovascular health. I plan to combine this with nattokinase for a synergistic effect, preventing blood clots and lowering cholesterol. This brand is good quality and the dosage is just right.
9
Effective blend
1 people found this helpful
I sought a natural supplement for healthy cholesterol levels and found this product effective. After taking two capsules daily for months, my cholesterol improved significantly. This affordable blend supports cardiovascular health without the need for prescription drugs.
7.5
Energy boost
2 people found this helpful
I found Faro Armelaze excellent for heart health, feeling a noticeable difference in energy levels. It is non-GMO and gluten-free, making it a safe choice. The combination of red yeast rice and Coenzyme Q10 provides powerful support for cardiovascular disease.
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.

The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.

Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
9
CoQ10 and trimetazidine effective
We explored the effectiveness of coenzyme Q10 (CoQ10) as a treatment for acute viral myocarditis (AVM) when combined with trimetazidine. This systematic review and meta-analysis looked at various randomized controlled trials to determine how well this combination therapy works compared to CoQ10 alone.

Our analysis included 16 trials with a total of 1,364 patients. Out of these, 687 were treated with both trimetazidine and CoQ10 for about 5 weeks, while another 677 received only CoQ10. We observed that the combination therapy significantly enhanced treatment effectiveness, improving overall outcomes with a risk ratio of 1.19. Importantly, this combined approach also showed better results regarding myocardial enzyme levels and the improvement of cardiac systolic function, without increasing adverse events.

From our findings, it appears that using trimetazidine together with CoQ10 offers a promising and safe option for patients dealing with AVM. Patients can gain more benefits from this duo compared to using CoQ10 alone, marking a significant advancement in treating this condition.

References

  1. Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. 10.14715/cmb/2025.70.1.13
  2. Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. 10.3760/cma.j.cn112137-20240605-01273
  3. Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. 10.1186/s12872-024-04232-z
  4. Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. 10.1080/14796678.2024.2352308
  5. Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. 10.47391/JPMA.S6-ACSA-16
  6. Vrentzos E, Ikonomidis I, Pavlidis G, Katogiannis K, Korakas E, et al. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial. Cardiovasc Diabetol. 2024;23:245. 10.1186/s12933-024-02326-8
  7. Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
  8. Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. 10.1016/j.freeradbiomed.2024.06.027
  9. Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. 10.3855/jidc.18776
  10. Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. 10.1161/CIRCULATIONAHA.123.067861
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